Standardized and Extended Catalog of Major Proteins of the Human Kidney

L. I. Obelchuk,¹ D. A. Tsomartova,¹ L. I. Kovalyov,^2,3 P. Z. Khasigov,¹ P. G. Rubachev,¹ S. V. Grachev,¹ S. S. Shishkin,² and T. T. Berezov⁴

¹Sechenov Moscow Medical Academy, Russian Ministry of Health Care and Medical Industry, ul. B. Pirogovskaya 2/6, Moscow, 119881 Russia; fax: (7-095) 248-01-81.

²Center for Medical Genetics, Russian Academy of Medical Sciences, ul. Moskvorech'e 1, Moscow, 115478 Russia; fax: (7-095) 324-07-02.

³To whom correspondence should be addressed.

⁴Medical School, Friendship of Nations University, ul. Miklukho-Maklaya 6, Moscow, 117198 Russia; fax: (7-095) 434-04-12.

Submitted September 10, 1996; revision submitted October 15, 1996.

A new version of a two-dimensional electrophoretic catalog of proteins of the human kidney and of various morphological and functional structures of the human kidney is presented; it contains information about 179 polypeptides. The following proteins were identified: crystallin, albumin, mitochondrial superoxide dismutase, actin, fatty acid-binding protein, alpha-ATP-synthase, and transferrin. Some protein groups are specific for certain morphological structures.

KEY WORDS: two-dimensional electrophoresis, human kidney proteins.

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