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Regulation Mechanisms of Mammalian Telomerase. A Review

F. Ishikawa1

1Tokyo Institute of Technology, Department of Life Science, 4259 Nagatsuta, Midori-ku, Yokohama, 226 Japan; fax: (8145) 924-5831; E-mail: fishikaw@bio.titech.ac.jp

Submitted September 21, 1997.
In this review, I summarize the most recent progress in the studies on mammalian telomerase, especially focusing on the molecular aspects. Possible regulation mechanisms of telomerase activity in mammalian cells are discussed.
KEY WORDS: telomerase, telomere, end replication problem, regulation.