Interaction of Reactive Oxygen Species with DNA. A Review

A. V. Peskin¹

¹Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 117808 Russia; fax: (095) 135-8012; E-mail: peskin@ibrran.msk.su

Submitted July 7, 1997; revision submitted July 17, 1997.

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Data on direct and indirect effects of reactive oxygen species on DNA are reviewed. The classification of the types of DNA oxidative damage and repair enzymes including glycosylases and endo- and exonucleases is presented. The regulatory function of reactive oxygen species and their role in carcinogenesis are discussed.

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KEY WORDS: DNA damage, oxygen radicals, DNA repair, cancer, apoptosis.

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