REVIEW: The Simplest Proline-Containing Peptides PG, GP, PGP, and GPGG: Regulatory Activity and Possible Sources of Biosynthesis

I. P. Ashmarin^*, E. P. Karazeeva, L. A. Lyapina, and G. E. Samonina

School of Biology, Lomonosov Moscow State University, Moscow, 119899 Russia; fax: (095) 939-3355; E-mail: ashmarin@3.human.bio.msu.ru

^* To whom correspondence should be addressed.

Received June 18, 1997

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Our own data and data from the literature on the regulatory role of the simplest proline-containing peptides GP, PG, PGP, GPGG, and cyclic-PG are summarized. These peptides are involved in homeostasis of gastric mucosa and the anticoagulant and fibrinolytic potential of blood plasma. They also potentiate memory consolidation processes in the central nervous system. The most probable sources of these peptides are polypeptide precursors of collagen, elastin, and enterostatin.

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KEY WORDS: proline-containing peptides, collagen, elastin, enterostatin, ulcer, gastric mucosa, fibrinolysis, antithrombosis, memory, regulatory peptide precursors

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