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REVIEW: Cytochrome P450-Dependent Metabolism of Arachidonic Acid

I. V. Ivanov*, N. V. Groza, and G. I. Myagkova

Lomonosov State Academy of Fine Chemical Technology, pr. Vernadskogo 86, Moscow, 117571 Russia; fax: (095) 434-8711; E-mail: myagkova@httos.mitht.msk.ru

* To whom correspondence should be addressed.

Received September 21, 1998; Revision received March 25, 1999
The cytochrome P450-dependent metabolism of arachidonic acid, the mechanisms of regulation of stereo- and regiospecificity by cytochrome P450 isoenzymes, and the biological relevance of metabolites of the arachidonic acid cascade is discussed in this review.
KEY WORDS: cytochrome P450, arachidonic acid, eicosanoids, epoxyeicosatrienoic acid, hydroxyeicosatetraenoic acid