2Bach Institute of Biochemistry, Russian Academy of Sciences, Leninskii pr. 33, Moscow, 117071 Russia; fax: (095) 954-2732; E-mail: firstname.lastname@example.org
* To whom correspondence should be addressed.
Received November 11, 1998; Revision received March 23, 1999
Peptidyl-prolyl cis-trans isomerases (PPI) catalyze cis-trans isomerization of imide bonds in peptides and proteins. This review summarizes the literature on the structure and functions of PPIs, their involvement in protein folding, and organization of PPI-containing receptors and membrane channels. A possible role of several PPIs in distant interactions between cells is discussed.
KEY WORDS: peptidyl-prolyl cis-trans isomerase, folding, catalysis mechanisms, multifunctionality, chaperones, immunophilins