2Department of Biochemistry, School of Medicine, Russian People's Friendship University, ul. Miklukho-Maklaya 8, Moscow, 117198 Russia; fax: (095) 434-0412; E-mail: email@example.com
3National Mental Health Research Center, Russian Academy of Medical Sciences, Zagorodnoe Shosse 2/2, Moscow, 113152 Russia; fax: (095) 952-8940; E-mail: firstname.lastname@example.org
* To whom correspondence should be addressed.
Received June 16, 1998; Revision received March 10, 1999
This review considers some aspects of the biochemistry of beta-amyloid, a protein which produces insoluble deposits in the brain. These deposits are a specific morphological feature of Alzheimer's disease, Down's syndrome, and senile dementia. Our contribution to the concept of a soluble form of beta-amyloid as of a normal human protein is presented.
KEY WORDS: Alzheimer's disease, beta-amyloid, beta-amyloid precursor, lipid metabolism