Stimulation of Nitrate Reductase Activity of the Salt-Tolerant Yeast Rhodotorula glutinis by Tungsten in the Presence of Molybdenum

A. N. Nosikov, E. V. Chichikalo, L. I. Golubeva, R. A. Zvyagilskaya, and N. P. L'vov^*

Bach Institute of Biochemistry, Russian Academy of Sciences, Leninskii pr. 33, Moscow, 117071 Russia; fax: (095) 954-2732; E-mail: inbio@glas.apc.org

^* To whom correspondence should be addressed.

Received April 23, 1999; Revision received October 4, 1999

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Tungsten in the presence of molybdenum stimulates nitrate reductase activity and growth of the salt-tolerant yeast Rhodotorula glutinis on medium with nitrates. Tungsten is not incorporated in proteins possessing nitrate reductase activity. A significant increase in molybdenum cofactor in cells grown on medium with equimolar amounts of molybdenum and tungsten may relate to the stimulatory action of tungsten.

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KEY WORDS: nitrate reductase, tungsten, molybdenum

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