REVIEW: alpha-Glucosidases

V. V. Krasikov, D. V. Karelov, and L. M. Firsov^*

Konstantinov St. Petersburg Nuclear Physics Institute, Gatchina, Leningrad Region, 188350 Russia; E-mail: firsov@lf4029.spb.edu

^* To whom correspondence should be addressed.

Received August 22, 2000

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This review highlights the main properties of mammalian, plant, and microbial alpha-glucosidases. Special attention is given to the classification of these enzymes, possible catalytic mechanisms, their tertiary structure, and the structure of major inhibitors. Experimental data on the elucidation of amino acid residues essential for catalysis are also discussed.

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KEY WORDS: alpha-glucosidases, classification, catalysis, catalytic nucleophiles, inhibitors

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