Received May 7, 2002
Modern approaches for developing antibodies with coenzyme-dependent activities are discussed for pyridoxal 5´-phosphate dependent transformation of amino acid as an example. A new type of antigens analogous to enzyme-substrate compounds is suggested for the production of such antibodies. Approaches for the development of pyridoxal antiidiotypic antibody using analogs of coenzyme-substrate compounds and corresponding apoenzyme complexes are reviewed.
KEY WORDS: transition state analogs, B6 enzymes, haptens, enzyme transition state analogs, coenzyme dependent catalytic antibody