REVIEW: Microbial Therapy of Cancer: Induction of Apoptosis, Recombinant Vaccines, and Inhibition of Angiogenesis

V. D. Samuilov

Department of Physiology of Microorganisms, Faculty of Biology, Lomonosov Moscow State University, Moscow 119992, Russia; fax: (7-095) 939-3807; E-mail: vds@8.cellimm.bio.msu.ru

Received January 30, 2003; Revision received March 3, 2003

---

This review presents diverse approaches to cancer biotherapy including bacteriolytic therapy aimed at inducing apoptosis in tumor cells, bacterial vector-based cancer vaccines, and inhibition of tumor neoangiogenesis by microorganisms. The normal microflora in humans and animals may restrain malignant tumor regeneration.

---

KEY WORDS: cancer, bacteriolytic therapy, vaccines, angiogenesis

---