Effect of High-Pressure Helium on Latex-Induced Activated Chemiluminescence of Human Blood Leucocytes

A. Yu. Tyurin-Kuz'min^* and A. V. Vdovin

Department of Hyperbaric Physiology, Shirshov Institute of Oceanology, Russian Academy of Sciences, Nakhimovsky pr. 36, Moscow 117851, Russia; fax: (7-095) 124-5983; E-mail: marina@ocean.ru

^* To whom correspondence should be addressed.

Received September 11, 2002; Revision received January 28, 2003

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High-pressure helium reduces the latex-induced activated chemiluminescence of diluted human blood. This effect is more noticeable, when lucigenin rather than luminol is used as the activator of chemiluminescence. The effect lessens in the presence of Mg²⁺ but not Ca²⁺. The data suggest the association of this effect with actin polymerization in leucocytes phagocytosing the latex particles.

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KEY WORDS: pressure, hyperbaria, chemiluminescence, leucocytes, blood, luminol, lucigenin, actin, phagocytosis, latex

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