Halogenating Enzymes in the Biosynthesis of Antibiotics

V. N. Burd^1* and K.-H. van Pee²

¹Grodno State University, ul. Dovatora 3/1, Grodno 230015, Belarus'; E-mail: burd@mail.grsu.grodno.by

²Institute of Biochemistry, Technical University, Dresden, Germany

^* To whom correspondence should be addressed.

Received February 11, 2003; Revision received April 4, 2003

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Using blot hybridization, it has been shown that microorganisms producing halogen-containing antibiotics--Pseudomonas pyrrocinia, P. aureofaciens ACN, P. aureofaciens Pa1, P. fluorescens CHA0, Actinoplanes sp., Kitasatasporia sp., Sacharothrix aerocolonigenes, Actinomadura melliaura, and Streptomyces albogriseolus--contain the genes of the halogenating enzymes related to tryptophan-7-halogenase and monodechloroaminopyrrolnitrin halogenase from P. fluorescens BL 915.

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KEY WORDS: halogenase, pyrrolnitrin, pentachloropseudilin, pyoluteorin, pyrroindomycin, rebeccamycin, thienodolin, Pseudomonas, Actinoplanes, Kitasatasporia, Sacharothrix, Actinomadura, Streptomyces

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