Special Features of the DNA-Hydrolyzing Activity of the Antibodies in Systemic Lupus Erythematosus

T. A. Nevzorova^*, D. A. Temnikov, and V. G. Vinter

Kazan State University, ul. Kremlevskaya 18, Kazan 420008, Russia; E-mail: Tatyana.Nevzorova@ksu.ru

^* To whom correspondence should be addressed.

Received February 12, 2003

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Two types of IgG anti-DNA antibodies exhibiting DNA-hydrolyzing activity have been isolated from blood serum of patients with systemic lupus erythematosus. This DNase activity of antibodies differs from serum DNases by the non-processive mode, temperature resistance, pH optimum, and the rate of DNA hydrolysis. It is suggested that the anti-DNA antibody molecule possessing DNase activity contains two sites: one site determines specificity of antibody-DNA interaction, whereas the other is responsible for manifestation of the catalytic activity.

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KEY WORDS: polyclonal catalytic antibodies, abzymes, systemic lupus erythematosus, IgG, DNA hydrolysis

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