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REVIEW: Cardiolipin in Energy Transducing Membranes

E. Mileykovskaya*, M. Zhang, and W. Dowhan

Department of Biochemistry and Molecular Biology, University of Texas-Houston, Medical School, Houston, TX 77030, USA; fax: (1-713) 500-0652; E-mail: Eugenia.Mileykovskaya@uth.tmc.edu

* To whom correspondence should be addressed.

Received September 23, 2004
Cardiolipin is a phospholipid located exclusively in energy transducing membranes such as the bacterial cytoplasmic membrane and the inner membrane of mitochondria. It plays both a structural and a functional role in many multimeric complexes associated with these membranes. The role of cardiolipin in higher order organization of components of the mitochondrial respiratory chain revealed by a combined molecular genetic and biochemical approach is described.
KEY WORDS: cardiolipin, supercomplex, yeast mitochondria