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REVIEW: Role of Biologically Active Sphingolipids in Tumor Growth

E. V. Dyatlovitskaya* and A. G. Kandyba

Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, 117997 Moscow, Russia; E-mail: dyatl@ibch.ru

* To whom correspondence should be addressed.

Received February 10, 2005; Revision received March 17, 2005
This review highlights the literature on the effects of biologically active sphingolipids (sphingosine, ceramide, sphingomyelin, glucosylceramide, gangliosides GM1, GM2, GM3, GD3, etc.) on proliferation, apoptosis, metastases, and invasiveness of tumor cells and the putative role of sphingolipids in chemotherapy of malignant tumors.
KEY WORDS: gangliosides, glucosylceramide, sphingosine, sphingolipids, sphingomyelin, sphingosine-1-phosphate, ceramide, tumor

DOI: 10.1134/S0006297906010020