* To whom correspondence should be addressed.
Received February 10, 2005; Revision received March 17, 2005
This review highlights the literature on the effects of biologically active sphingolipids (sphingosine, ceramide, sphingomyelin, glucosylceramide, gangliosides GM1, GM2, GM3, GD3, etc.) on proliferation, apoptosis, metastases, and invasiveness of tumor cells and the putative role of sphingolipids in chemotherapy of malignant tumors.
KEY WORDS: gangliosides, glucosylceramide, sphingosine, sphingolipids, sphingomyelin, sphingosine-1-phosphate, ceramide, tumor