REVIEW: Biochemistry of Prostaglandins A

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A. I. Hubich and M. V. Sholukh^*

Belarus State University, pr. Nezavisimosty 4, 220050 Minsk, Belarus; fax: (+375) 172-125-535; E-mail: sholukh@bsu.by

^* To whom correspondence should be addressed.

Received May 5, 2005; Revision received June 21, 2005

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This review considers modern concepts on the structural-functional properties and antiproliferative, antitumor, and antiviral effects of cyclopentenone prostaglandins A and mechanisms underlying their actions. Possible directions of pharmacological application of these compounds and their analogs are discussed.

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KEY WORDS: prostaglandins, arachidonic acid, heat shock proteins, cell cycle, prostanoid receptors, thermotolerance, antiviral activity

DOI: 10.1134/S0006297906030011

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