REVIEW: Proteins Involved in Binding and Cellular Uptake of Nucleic Acids

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B. P. Chelobanov^1*, P. P. Laktionov², and V. V. Vlasov²

¹Institute of Biochemistry, Siberian Branch of the Russian Academy of Medical Sciences, ul. Akademika Timakova 2, 630117 Novosibirsk, Russia; fax: (383) 333-6758; E-mail: chelobanov@soramn.ru

²Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, pr. Akademika Lavrentieva 8, 630090 Novosibirsk, Russia; fax: (383) 333-3677; E-mail: lakt@niboch.nsc.ru

^* To whom correspondence should be addressed.

Received September 30, 2005; Revision received April 3, 2006

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The study of mechanisms of nucleic acid transport across the cell membrane is valuable both for understanding the biological function of extracellular nucleic acids and the practical use of nucleic acids in gene therapy. It has been clearly demonstrated that cell surface proteins are necessary for transport of nucleic acids into cells. A large amount of data has now been accumulated about the proteins that participate in nucleic acid transport. The methods for revealing and identification of these proteins, possible mechanisms of protein-mediated transport of nucleic acids, and cellular functions of these proteins are described.

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KEY WORDS: oligonucleotides, oligonucleotide-binding proteins, nucleic acid receptors, nucleic acid uptake

DOI: 10.1134/S0006297906060010

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