Received December 21, 2006; Revision received February 5, 2007
This review considers biochemical aspects of inflammation. The international literature until December 2006 has been analyzed, with the principal attention paid to the most dynamic problems: enzymology of inflammation, its regulation by hormones and signal transducers, and negative feedbacks, which underlie intensive current studies on pathogenesis, diagnostics, and therapy of inflammation. Such achievements as discoveries of defensins, toll-like receptors, interconnections of inflammation and iron metabolism, the roles of oxidative stress and antioxidant defense, lipoxins, inflammatory components of non-inflammatory diseases, and action mechanisms of effective drugs are discussed.
KEY WORDS: inflammation, enzymes, cytokines, hormones, immune response