REVIEW: Induction of Cytochrome P4502B: Role of Regulatory Elements and Nuclear Receptors

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V. O. Pustylnyak^*, L. F. Gulyaeva, and V. V. Lyakhovich

Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, ul. Akademika Timakova 2, 630117 Novosibirsk, Russia; fax: (383) 323-3147; E-mail: pustylnyak@ngs.ru

^* To whom correspondence should be addressed.

Received February 5, 2007; Revision received March 1, 2007

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Cytochrome P450 of the 2B subfamily is easily induced by many xenobiotics. In spite of intensive investigations, the molecular mechanisms of regulation of the CYP2B genes are not clear. The nuclear receptor CAR is shown to play a crucial role in the activation of CYP2B genes by xenobiotics, but many problems of CAR activation in different animal species and humans remain unsolved. This review focuses on signaling pathways involved in the control of CYP2B gene expression in mammals.

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KEY WORDS: CYP2B, phenobarbital, induction, nuclear receptors, CAR

DOI: 10.1134/S000629790706003X

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