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STAT1 Gene Expression in Cervical Carcinomas

G. V. Volgareva1, D. A. Golovina1, N. M. Gasparjan1, V. D. Ermilova1, L. S. Pavlova1, A. A. Petrenko1, M. N. Fedorova1, L. K. Kurbatov2, I. B. Cheglakov2, K. N. Jarigin2, and F. L. Kisseljov1*

1Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Kashirskoe Shosse 24, 115478 Moscow, Russia; fax: (495) 324-1205; E-mail: f_kiss@crc.umos.ru

2Orekhovich Institute of Biological and Medical Chemistry, Russian Academy of Medical Sciences, ul. Pogodinskaya 10, 110121 Moscow, Russia

* To whom correspondence should be addressed.

Received February 1, 2007; Revision received March 22, 2007
Expression of the STAT1 gene belonging to the group of interferon-regulated genes was analyzed in cervical tumors and cell lines harboring the genome of human papilloma viruses (HPV) of so-called high risk group. Expression of this gene in invasive carcinomas was maintained on a definite level that was not significantly distinct from that in adjacent normal (control) tissue. Tumors from different patients differ from each other by expression level of the STAT1 gene. These variations can be attributed to the heterogeneity of tumor cell population and different ratio between normal and tumor cells, as well as to putative persistence of intra-individual variability of STAT1 expression in normal cell population. It was demonstrated that viral genome status (episomal or integrative) did not influence STAT1 gene transcription. In conclusion, these data demonstrate that the STAT1 gene is expressed in an individual and specific manner both in HPV-positive cervical tumors and cell lines harboring transforming genes of these viruses.
KEY WORDS: cervical cancer, human papilloma viruses, interferon-regulated genes

DOI: 10.1134/S0006297907070115