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Effects of Lipoic Acid on Citrate Content, Aconitate Hydratase Activity, and Oxidative Status during Myocardial Ischemia in Rats

A. V. Makeeva*, T. N. Popova, L. V. Matasova, and I. N. Yama

Faculty of Biology and Soil Sciences, Voronezh State University, Universitetskaya pl. 1, 394006 Voronezh, Russia; fax: (4732) 208-755; E-mail: voloskova@bio.vsu.ru

* To whom correspondence should be addressed.

Received February 20, 2007; Revision received July 31, 2007
The effects of lipoic acid on intensity of free radical reactions, citrate content, and aconitate hydratase during myocardial ischemia have been investigated. Treatment with lipoic acid normalized biochemiluminescence parameters and citrate level, which were increased in the myocardial pathology. Treatment with lipoic acid also increased specific activity of aconitate hydratase, which was decreased in myocardium and blood of animals with myocardial ischemia. Administration of lipoic acid decreased DNA fragmentation observed during myocardial ischemia. The data suggest that lipoic acid can be effectively used as a cardioprotector preventing the development of free radical oxidation during myocardial ischemia.
KEY WORDS: myocardial ischemia, lipoic acid, citrate, aconitate hydratase

DOI: 10.1134/S0006297908010112