* To whom correspondence should be addressed.
Received June 27, 2007; Revision received August 3, 2007
Eight different mouse myostatin small interfering RNA (siRNAs) were synthesized and tested. Five siRNAs showed a pronounced biological effect reducing myostatin mRNA content. For two of them, the myostatin mRNA level was reduced 3- and 4-fold, respectively. The obtained siRNAs can be used for study of biological effects of myostatin, both in vitro and in vivo.
KEY WORDS: myostatin, siRNA, RNA interference, myoblasts