siRNAs Targeting Mouse Myostatin

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V. A. Furalyov, I. V. Kravchenko, V. P. Khotchenkov, and V. O. Popov^*

Bach Institute of Biochemistry, Russian Academy of Sciences, Leninsky pr. 33, 119071 Moscow, Russia; fax: (495) 954-2732; E-mail: vpopov@inbi.ras.ru

^* To whom correspondence should be addressed.

Received June 27, 2007; Revision received August 3, 2007

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Eight different mouse myostatin small interfering RNA (siRNAs) were synthesized and tested. Five siRNAs showed a pronounced biological effect reducing myostatin mRNA content. For two of them, the myostatin mRNA level was reduced 3- and 4-fold, respectively. The obtained siRNAs can be used for study of biological effects of myostatin, both in vitro and in vivo.

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KEY WORDS: myostatin, siRNA, RNA interference, myoblasts

DOI: 10.1134/S0006297908030164

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