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Evolution of DNA Polymerase iota Structure and Function in Eukaryotes

A. V. Makarova*, V. Z. Tarantul, and L. V. Gening

Institute of Molecular Genetics, Russian Academy of Sciences, pl. Kurchatova 2, 123182 Moscow, Russia; fax: (499) 196-0221; E-mail: amakarova-img@yandex.ru

* To whom correspondence should be addressed.

Received July 6, 2007; Revision received September 18, 2007
Analysis of DNA polymerase iota (Pol iota) enzymic activity in different classes of eukaryotes has shown that error-prone activity of this enzyme can be found only in mammals, and that it is completely absent from organisms that are at lower stages of development. It was supposed that the emergence of the error-prone Pol iota activity in mammals is caused by structural alteration of the active center. Possible functions of error-prone Pol iota in higher eukaryotes are discussed.
KEY WORDS: DNA polymerase iota, error-prone activity, hypermutagenesis

DOI: 10.1134/S0006297908030176