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REVIEW: The Centrosome Is a Polyfunctional Multiprotein Cell Complex

I. B. Alieva1 and R. E. Uzbekov1,2*

1Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia; E-mail: irina_alieva@belozersky.msu.ru

2Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119992 Moscow, Russia; fax: (495) 939-3181; E-mail: rustuzbekov@aol.com

* To whom correspondence should be addressed.

Received August 20, 2007; Revision received November 12, 2007
Contemporary knowledge about centrosome proteins and their ensembles, which can be divided into several functional groups--microtubule-nucleating proteins, microtubule-anchoring proteins, centriole-duplication proteins, cell cycle control proteins, primary cilia growth regulation proteins, and proteins of regulation of cytokinesis--is reviewed. Structural-temporal classification of centrosomal proteins and the scheme of interconnection between the different centrosomal protein complexes are presented.
KEY WORDS: proteins, centrosome, centriole, microtubules, cell cycle

DOI: 10.1134/S0006297908060023