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REVIEW: Aconitate Hydratase of Mammals under Oxidative Stress

L. V. Matasova* and T. N. Popova

Voronezh State University, Universitetskaya pl. 1, 394006 Voronezh, Russia; fax: (4732) 208-755; E-mail: matasova@bio.vsu.ru

* To whom correspondence should be addressed.

Received August 28, 2007; Revision received December 20, 2007
Data on the structure, functions, regulation of activity, and expression of cytosolic and mitochondrial aconitate hydratase isoenzymes of mammals are reviewed. The role of aconitate hydratase and structurally similar iron-regulatory protein in maintenance of homeostasis of cell iron is described. Information on modifications of the aconitate hydratase molecule and changes in expression under oxidative stress is generalized. The role of aconitate hydratase in the pathogenesis of some diseases is considered.
KEY WORDS: aconitase, citrate, oxidative stress, iron, iron-regulatory proteins, regulation of activity and expression

DOI: 10.1134/S0006297908090010