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REVIEW: Role of Acidosis, NMDA Receptors, and Acid-Sensitive Ion Channel 1a (ASIC1a) in Neuronal Death Induced by Ischemia

N. K. Isaev1,2*, E. V. Stelmashook2, E. Y. Plotnikov1, T. G. Khryapenkova1, E. R. Lozier3, Y. V. Doludin3, D. N. Silachev1, and D. B. Zorov1

1Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia; fax: (495) 939-3181; E-mail: isaev@genebee.msu.su

2Brain Research Department, Scientific Center of Neurology, Russian Academy of Medical Sciences, Pereulok Obukha 5, 105064 Moscow, Russia

3Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119992 Moscow, Russia

* To whom correspondence should be addressed.

Received January 31, 2008; Revision received February 13, 2008
This review collects data on the influence of intracellular and extracellular acidosis on neuronal viability and the effect of acidosis on neuronal damage progressing under brain ischemia/hypoxia. Particular attention is devoted to the involvement of ionotropic glutamic receptors and acid-sensitive ion channel 1a in these processes.
KEY WORDS: acidosis, neurons, ischemia/hypoxia, pH, ASIC1a

DOI: 10.1134/S0006297908110011