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REVIEW: D-Amino Acid Oxidase: Physiological Role and Applications

S. V. Khoronenkova1,2 and V. I. Tishkov1,3*

1Chemistry Faculty, Lomonosov Moscow State University, 119992 Moscow, Russia; E-mail: vitishkov@gmail.com; vit@enz.chem.msu.ru

2Innovations and High Technologies MSU Ltd., 109559 Moscow, Russia

3Bach Institute of Biochemistry, Russian Academy of Sciences, Leninsky pr. 32, 119071 Moscow, Russia

* To whom correspondence should be addressed.

Received June 27, 2008; Revision received August 13, 2008
D-Amino acids play a key role in regulation of many processes in living cells. FAD-dependent D-amino acid oxidase (DAAO) is one of the most important enzymes responsible for maintenance proper level of D-amino acids. The most interesting and important data for regulation of the nervous system, hormone secretion, and other processes by D-amino acids as well as development of different diseases under changed DAAO activity are presented. The mechanism of regulation is complex and multi-parametric because the same enzyme simultaneously influences the level of different D-amino acids, which can result in opposing effects. Use of DAAO for diagnostic and therapeutic purposes is also considered.
KEY WORDS: D-amino acid oxidase, physiological role, practical application

DOI: 10.1134/S0006297908130105