2Institute of Protein Research, Russian Academy of Sciences, ul. Institutskaya 4, 142290 Pushchino, Russia; fax: (499) 135-2147; E-mail: email@example.com
* To whom correspondence should be addressed.
Received March 28, 2009; Revision received May 18, 2009
Here we discuss some common mechanisms of microtubule-dependent active transport of nonmembranous components in animal cells. We summarize data about mRNA, cytoskeletal elements, structural proteins, and signaling complexes transport. We also characterize the series of molecular interactions that connect nonmembranous cargoes and microtubules and describe the regulatory pathways for these interactions.
KEY WORDS: cytoskeleton, microtubules, kinesin, dynein, transport, mRNA, signal transduction