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REVIEW: Conformational Dynamics and Pre-Steady-State Kinetics of DNA Glycosylases

O. S. Fedorova*, N. A. Kuznetsov, V. V. Koval, and D. G. Knorre

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, pr. Lavrent’eva 8, 630090 Novosibirsk, Russia; fax: +7 (383) 363-5153; E-mail: fedorova@niboch.nsc.ru

* To whom correspondence should be addressed.

Received March 10, 2010; Revision received April 30, 2010
Results of investigations of E. coli DNA glycosylases using pre-steady-state kinetics are considered. Special attention is given to the connection of conformational changes in the interacting biomolecules with kinetic mechanisms of the enzymatic processes.
KEY WORDS: conformational dynamics, pre-steady-state kinetics, DNA glycosylases

DOI: 10.1134/S0006297910100044