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REVIEW: Endogenous Opioid Peptides in Regulation of Innate Immunity Cell Functions

S. V. Gein1,2* and T. A. Baeva1

1Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences, ul. Goleva 13, 614081 Perm, Russia; E-mail: gein@iegm.ru

2Perm State University, ul. Bukireva 15, 614990 Perm, Russia

* To whom correspondence should be addressed.

Received May 12, 2010; Revision received October 26, 2010
Endogenous opioid peptides comprise a group of bioregulatory factors involved in regulation of functional activity of various physiological systems of an organism. One of most important functions of endogenous opioids is their involvement in the interaction between cells of the nervous and immune systems. Summary data on the effects of opioid peptides on regulation of functions of innate immunity cells are presented.
KEY WORDS: opioid peptides, opiate receptors, immunoregulatory effects, monocytes/macrophages, neutrophils, NK cells, dendritic cells, cAMP

DOI: 10.1134/S0006297911030035