REVIEW: Endogenous Opioid Peptides in Regulation of Innate Immunity Cell Functions

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S. V. Gein^1,2* and T. A. Baeva¹

¹Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences, ul. Goleva 13, 614081 Perm, Russia; E-mail: gein@iegm.ru

²Perm State University, ul. Bukireva 15, 614990 Perm, Russia

^* To whom correspondence should be addressed.

Received May 12, 2010; Revision received October 26, 2010

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Endogenous opioid peptides comprise a group of bioregulatory factors involved in regulation of functional activity of various physiological systems of an organism. One of most important functions of endogenous opioids is their involvement in the interaction between cells of the nervous and immune systems. Summary data on the effects of opioid peptides on regulation of functions of innate immunity cells are presented.

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KEY WORDS: opioid peptides, opiate receptors, immunoregulatory effects, monocytes/macrophages, neutrophils, NK cells, dendritic cells, cAMP

DOI: 10.1134/S0006297911030035

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