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Metabolic Dysfunction and Relationship in Human Frontoparietal Cortex in Severe Traumatic Brain Injury: Single-Voxel 1H Magnetic Resonance Spectroscopy Study

N. A. Semenova1*, T. A. Akhadov2, A. V. Petryaykin2, S. S. Sidorin1,2, A. V. Lukovenkov1, and S. D. Varfolomeev1

1Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina 4, 119334 Moscow, Russia; fax: (495) 137-4101; E-mail: nmr-semen@mail.ru

2Children’s Clinical and Research Institute of Emergency Surgery and Trauma, ul. Bolshaya Polyanka 22, 119180 Moscow, Russia; fax: (495) 959-5237; E-mail: akhadov@mail.ru

* To whom correspondence should be addressed.

Received September 22, 2011; Revision received December 26, 2011
1H-magnetic resonance spectroscopy revealed that apparently normal (from the data of magnetic resonance imaging) human brain frontoparietal cortex in the subacute stage of traumatic brain injury is characterized by decreased level of N-acetylaspartate (NAA) and increase in levels of myoinositol, choline-containing compounds (Cho), and creatine/phosphocreatine (Cr). Correlations between Cr, Cho, and NAA were established. We propose a scheme of neuronal metabolic processes that joins these substances.
KEY WORDS: magnetic resonance spectroscopy, severe traumatic brain injury, frontoparietal cortex

DOI: 10.1134/S0006297912040104