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Effect of Plastoquinone Derivative 10-(6′-Plastoquinonyl) Decyltriphenylphosphonium (SkQ1) on Estrous Cycle and 17β-Estradiol Level in Rats

V. A. Chistyakov1,2*, S. V. Dem’yanenko1,2, A. A. Alexandrova1, L. V. Gutnikova1, V. N. Prokof’ev1, and O. N. Kosheleva1

1Research Institute of Biology of Southern Federal University, pr. Stachki 194/1, 344090 Rostov-on-Don, Russia; fax: (863) 299-5661; E-mail: vladimirchi@yandex.ru

2Central Research Laboratory, Rostov State Medical University, Pereulok Nakhichevansky 29, 344022 Rostov-on-Don, Russia

* To whom correspondence should be addressed.

Received March 3, 2012; Revision received April 28, 2012
Administration of the plastoquinone derivative 10-(6′-plastoquinonyl)decyltriphenylphosphonium (SkQ1) to female Wistar rats with regular estrous cycle once a day for two weeks at doses of 25 nmol/kg (but not 250 nmol/kg) leads to increase in proestrus duration by reducing the phase of diestrus and metestrus. Neither dose caused significant changes in serum 17β-estradiol level for any stage of the cycle. However, relative elongation of the proestrus stage leads to an increase in average per cycle estradiol levels by 20%.
KEY WORDS: SkQ1, penetrating cations, estradiol, estrous cycle

DOI: 10.1134/S0006297912120061