2Central Research Laboratory, Rostov State Medical University, Pereulok Nakhichevansky 29, 344022 Rostov-on-Don, Russia
* To whom correspondence should be addressed.
Received March 3, 2012; Revision received April 28, 2012
Administration of the plastoquinone derivative 10-(6′-plastoquinonyl)decyltriphenylphosphonium (SkQ1) to female Wistar rats with regular estrous cycle once a day for two weeks at doses of 25 nmol/kg (but not 250 nmol/kg) leads to increase in proestrus duration by reducing the phase of diestrus and metestrus. Neither dose caused significant changes in serum 17β-estradiol level for any stage of the cycle. However, relative elongation of the proestrus stage leads to an increase in average per cycle estradiol levels by 20%.
KEY WORDS: SkQ1, penetrating cations, estradiol, estrous cycle