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REVIEW: Structural Organization of Viral RNA-Dependent RNA Polymerases

G. S. Shatskaya* and T. M. Dmitrieva

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia; fax: (495) 939-3181; E-mail: barsa19@rambler.ru

* To whom correspondence should be addressed.

Received September 18, 2012; Revision received November 2, 2012
This review describes available data on the structure of viral RNA-dependent RNA polymerases (RdRP) obtained from X-ray analysis and discusses the functional significance of the structural elements of these enzymes. Because most of the studies done to date relate to RdRP structures of picorna-, flavi-, and caliciviruses, here we consider mostly the structures of RdRP of these groups of viruses, and also include information about polymerases of other virus families.
KEY WORDS: RNA-dependent RNA polymerase, viral proteins, picornaviruses, polymerase structure

DOI: 10.1134/S0006297913030036