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Received November 21, 2012
A hypothesis is proposed about the involvement of mitochondria in transduction of intracellular signals. In addition to the endoplasmic reticulum responsible for fluctuations of intracellular concentration of Ca2+, mitochondria are supposed to determine changes in the concentration of the secondary messenger cAMP. This hypothesis extends our ideas concerning mechanisms of intracellular signal transduction.
KEY WORDS: endoplasmic reticulum, calcium, mitochondria, cAMP