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REVIEW: Regulation of Activity of Transcription Factor NF-κB by Synthetic Oligonucleotides

V. G. Metelev, E. A. Kubareva, and T. S. Oretskaya*

Faculty of Chemistry, Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninsky Gory 1, 119991 Moscow, Russia; E-mail: metelev@belozersky.msu.ru; kubareva@belozersky.msu.ru; oretskaya@belozersky.msu.ru

* To whom correspondence should be addressed.

Received April 12, 2013
Eukaryotic dimeric nuclear factor-κB (NF-κB) is one of the main transcription factors that activate expression of genes, products of which play the key role in development of cardiovascular pathologies, carcinogenesis, and inflammatory and viral diseases. In this review, the main attention is given to modulation of the transcription factor NF-κB activity by antisense oligonucleotides and oligonucleotide decoys. Also, current concepts about interactions between NF-κB dimers and DNA and general problems that arise in experimental use of synthetic oligonucleotides in vivo are discussed.
KEY WORDS: transcription factor NF-κB, modified oligonucleotides, antisense oligonucleotides, oligonucleotides decoys, aptamers

DOI: 10.1134/S0006297913080026