Is an Expression System for Producing Therapeutic Antibodies with Immunosuppressive Properties Found at Last? Comment to Letter by Dr. Quagliaroli

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N. I. Olovnikova

Hematology Research Center, Ministry of Health, Novyi Zykovskii Proezd 4A, 125167 Moscow, Russia; fax: (495) 612-3521; E-mail: nolov@blood.ru

Received September 9, 2013

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The prophylaxis of the hemolytic disease of the newborn – a mandatory procedure in obstetrics – requires significant amounts of plasma-derived polyclonal anti-D immunoglobulin. Despite numerous attempts, the proper technology for mass production of effective monoclonal anti-D is still not available. LFB Biotechnologies is currently performing clinical trials with recombinant anti-D antibody that has low fucose content and is expressed in the cells of rat myeloma YB2/0. It was shown that this drug is well tolerated, accelerates fast clearance of D+ red blood cells, and can inhibit anti-D immune response in Rhesus-negative volunteers.

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KEY WORDS: anti-D monoclonal antibodies, Roledumab, glycosylation, alloimmunization, clinical trials

DOI: 10.1134/S0006297913120092

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