2Perm State University, ul. Bukireva 15, 614990 Perm, Russia
Received October 28, 2013; Revision received January 9, 2014
Dynorphins constitute a family of opioid peptides manifesting the highest affinity for κ-opiate receptors. Immune system cells are known to express a κ-receptor similar to that in the central nervous system, and as a consequence dynorphins are involved in the interaction between cells of the nervous and immune systems. In this review, data on dynorphin structure are analyzed and generalized, the κ-opiate receptor is characterized, and data on the regulation by dynorphins of functioning of the innate and adaptive immunity cells are summarized.
KEY WORDS: dynorphin, κ-opiate receptor, immunoregulatory effects, monocytes/macrophages, lymphocytes, NK-cells, dendritic cells, cAMP