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REVIEW: AMP-Activated Protein Kinase: Structure, Function, and Role in Pathological Processes

D. S. Novikova*, A. V. Garabadzhiu, G. Melino, N. A. Barlev, and V. G. Tribulovich

Saint Petersburg State Technological Institute (Technical University), Moskovsky pr. 26, 190013 St. Petersburg, Russia; fax: +7 (812) 316-4648; E-mail: dc.novikova@gmail.com

* To whom correspondence should be addressed.

Received July 5, 2014; Revision received September 12, 2014
Recently, AMP-activated protein kinase (AMPK) has emerged as a key regulator of energy balance at cellular and whole-body levels. Due to the involvement in multiple signaling pathways, AMPK efficiently controls ATP-consuming/ATP-generating processes to maintain energy homeostasis under stress conditions. Loss of the kinase activity or attenuation of its expression leads to a variety of metabolic disorders and increases cancer risk. In this review, we discuss recent findings on the structure of AMPK, its activation mechanisms, as well as the consequences of its targets in regulation of metabolism. Particular attention is given to low-molecular-weight compounds that activate or inhibit AMPK; the perspective of therapeutic use of such modulators in treatment of several common diseases is discussed.
KEY WORDS: AMP-activated protein kinase, energy metabolism, metabolic syndrome, diabetes type 2, cancer, AMPK activators, AMPK inhibitors

DOI: 10.1134/S0006297915020017