2Lomonosov Moscow State University, Institute of Mitoengineering, 119991 Moscow, Russia; E-mail: firstname.lastname@example.org
3Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology, 119991 Moscow, Russia; fax: +7 (495) 939-3161; E-mail: email@example.com
* To whom correspondence should be addressed.
Received November 25, 2014
A single intraperitoneal injection to rats of the mitochondria-targeted plastoquinone antioxidant SkQR1 at dose 1 µmol/kg significantly improved reproduction by the rats of the passive avoidance conditional reflex. In vitro experiments on hippocampal slices showed that a single intraperitoneal injection of SkQR1 24 h before the preparation of the slice significantly increases the synaptic transmission efficiency of the pyramidal neurons of the CA1 field. The findings indicate that SkQR1 has a positive effect on memory processes.
KEY WORDS: memory, long-term potentiation, hippocampus, mitochondria-targeted antioxidants, SkQR1