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MINI-REVIEW: Heat Stress-Induced Transcriptional Repression

O. L. Kantidze1, A. K. Velichko1, and S. V. Razin1,2*

1Institute of Gene Biology, Russian Academy of Sciences, ul. Vavilova 34/5, 119334 Moscow, Russia; fax: +7 (499) 135-4105; E-mail: sergey.v.razin@usa.net

2Lomonosov Moscow State University, Faculty of Biology, 119991 Moscow, Russia; fax: +7 (495) 939-4309

* To whom correspondence should be addressed.

Received February 25, 2015; Revision received April 9, 2015
Heat stress is one of the most popular models for studying the regulation of gene expression. For decades, researchers’ attention was focused on the study of the mechanisms of transcriptional activation of stress-induced genes. Although the phenomenon of heat stress-induced global transcriptional repression is known for a long time, the exact molecular mechanisms of such a repression are poorly explored. In this mini-review, we attempt to summarize the existing experimental data on heat stress-induced transcriptional repression.
KEY WORDS: transcription, gene expression, heat shock, RNA polymerase II, RNA polymerase III, SINE, CGGBP1

DOI: 10.1134/S0006297915080039