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Inhibitory Effect of Polyethylene Oxide and Polypropylene Oxide Triblock Copolymers on Aggregation and Fusion of Atherogenic Low Density Lipoproteins

I. G. Panova1*, V. V. Spiridonov1, I. B. Kaplan2, S. S. Trubinov3, N. V. Elizova3, A. A. Melnichenko3, A. N. Orekhov3, and A. A. Yaroslavov1

1Lomonosov Moscow State University, Faculty of Chemistry, 119991 Moscow, Russia; fax: +7 (495) 939-8846; E-mail: igpan@mail.ru

2Lomonosov Moscow State University, Faculty of Biology, 119991 Moscow, Russia; fax: +7 (495) 939-2776

3Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 125315 Moscow, Russia; fax: +7 (495) 601-2366

* To whom correspondence should be addressed.

Received November 27, 2014; Revision received January 12, 2015
Triblock copolymers of poly(ethylene oxide) and poly(propylene oxide) (so-called pluronics) were shown to influence the aggregation and fusion of atherogenic low density lipoproteins (atLDL) and be able to inhibit these processes. The character of the influence and the degree of the stabilizing effect depended on the structure, relative hydrophobicity, and concentration of the copolymer. Pluronics L61, P85, and L64 characterized by the hydrophilic–lipophilic balance (HLB) value from 3 to 16 had the greatest ability to suppress the aggregation of atLDL. Pluronic L81 with the higher hydrophobicity (HLB = 2) partially inhibited atLDL aggregation at low concentrations but stimulated it at high concentrations. The influence of pluronics did not have a direct connection with their ability for micelle formation, but it was realized through individual macromolecules. We suppose that effects of pluronics could be due to their interaction with the lipid component of LDL and to a possible influence of these copolymers on the structure and hydrophilic–lipophilic characteristics of lipoproteins.
KEY WORDS: low density lipoproteins, pluronics, triblock copolymers of poly(ethylene oxide) and poly(propylene oxide), atherosclerosis, anti-atherogenicity, inhibition of aggregation and fusion

DOI: 10.1134/S0006297915080118