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REVIEW: Age-Related Changes in Ultrastructure of Mitochondria. Effect of SkQ1

L. E. Bakeeva

Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology, 119991 Moscow, Russia; fax: +7 (495) 939-3181; E-mail: bakeeva@belozersky.msu.ru

Received July 7, 2015
For many years, investigators have attempted to identify unique ultrastructural conditions of mitochondria related to aging. However, this did not result in definitive results. At present, this issue has again become of topical interest due to development of the mitochondrial theory of aging and of engineering of a novel antioxidant class known as mitochondria-targeted antioxidants. The review briefly discusses experimental results that, from our perspective, allow the most objective understanding regarding age-related changes in mitochondrial ultrastructure.
KEY WORDS: aging, mitochondrial ultrastructure, age-related changes

DOI: 10.1134/S0006297915120068