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REVIEW: Plant Phenols and Autophagy

N. K. Zenkov1, A. V. Chechushkov1, P. M. Kozhin1, N. V. Kandalintseva2, G. G. Martinovich3, and E. B. Menshchikova1*

1Research Institute of Experimental and Clinical Medicine, Novosibirsk 630117, Russia; fax: +7 (383) 333-6456; E-mail: lemen@centercem.ru

2Novosibirsk State Pedagogical University, 630126 Novosibirsk, Russia; fax: +7 (383) 244-1161; E-mail: nspu@nspu.net

3Belarusian State University, 220030 Minsk, Belarus; fax: +7 (375) 17-209-5267; E-mail: martinovichgg@bsu.by

* To whom correspondence should be addressed.

Received October 23, 2015; Revision received November 19, 2015
Many plant phenols (stilbenes, curcumins, catechins, flavonoids, etc.) are effective antioxidants and protect cells during oxidative stress. Extensive clinical studies on the potential of phenolic compounds for treatment of cardiovascular, neurodegenerative, oncological, and inflammatory diseases are now being conducted. In addition to direct antioxidant effect, plant phenols may provide a protective effect via activation of the Keap1/Nrf2/ARE redox-sensitive signaling system and regulation of autophagy. In this review, mechanisms of effects of the most common plant phenols on autophagy are presented.
KEY WORDS: phenolic antioxidants, autophagy, Keap1/Nrf2/ARE signaling system, regulation

DOI: 10.1134/S0006297916040015