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REVIEW: Role of Nuclear Constitutive Androstane Receptor in Regulation of Hepatocyte Proliferation and Hepatocarcinogenesis

Y. A. Kazantseva1, Y. A. Pustylnyak1,2, and V. O. Pustylnyak1,2*

1Institute of Molecular Biology and Biophysics, 630117 Novosibirsk, Russia

2Novosibirsk State University, 630090 Novosibirsk, Russia; fax: + 7 (383) 363-4008; E-mail: pustylnyak@ngs.ru

* To whom correspondence should be addressed.

Received October 28, 2015; Revision received December 4, 2015
Activation of the constitutive androstane receptor (CAR) in hepatocytes occurs as a body adaptation in response to a number of external influences, and its functional activity is primarily related to induction of enzymes detoxifying xenobiotics. However, special attention was recently given to CAR due to the fact that its key role becomes unveiled in various physiological and pathophysiological processes occurring in the liver: gluconeogenesis, metabolism of fatty acids and bilirubin, hormonal regulation, proliferation of hepatocytes, and hepatocarcinogenesis. Here we review the main pathways and mechanisms that elevate hepatocyte proliferative activity related to CAR and whose disturbance may be a pivotal factor in hepatocarcinogenesis.
KEY WORDS: CAR, activation of gene expression, ligands, proliferation, hepatocarcinogenesis

DOI: 10.1134/S0006297916040040