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REVIEW: Myosin Light Chain Kinase MYLK1: Anatomy, Interactions, Functions, and Regulation

A. Y. Khapchaev1,2* and V. P. Shirinsky1

1Russian Cardiology Research and Production Center, 121552 Moscow, Russia; E-mail: askerkhapcha@gmail.com

2Lomonosov Moscow State University, Faculty of Fundamental Medicine, 119192, Moscow, Russia

* To whom correspondence should be addressed.

Received September 12, 2016
This review discusses and summarizes the results of molecular and cellular investigations of myosin light chain kinase (MLCK, MYLK1), the key regulator of cell motility. The structure and regulation of a complex mylk1 gene and the domain organization of its products is presented. The interactions of the mylk1 gene protein products with other proteins and posttranslational modifications of the mylk1 gene protein products are reviewed, which altogether might determine the role and place of MLCK in physiological and pathological reactions of cells and entire organisms. Translational potential of MLCK as a drug target is evaluated.
KEY WORDS: myosin light chain kinase, KRP/telokin, mylk1 gene organization and regulation, posttranslational modifications, protein–protein interactions, MLCK-dependent cellular reactions, MLCK in pathology

DOI: 10.1134/S000629791613006X