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Response to Comments by V. N. Manskikh: “Do External or Internal Factors Lead to Tumor Development? It Is Still Unknown”

A. V. Lichtenstein

Blokhin Cancer Research Center, Institute of Carcinogenesis, 115478 Moscow, Russia; E-mail: alicht@mail.ru

Received September 12, 2016
The opinion is presented according to which the “bad luck” hypothesis (Tomasetti, C., and Vogelstein, B. (2015) Science, 347, 78-81), which has recently received experimental confirmation, has the right to exist, and its criticisms are largely unfounded.
KEY WORDS: cancer, “bad luck” hypothesis, carcinogenesis, mutagenesis, external and internal factors, cancer prevention

DOI: 10.1134/S0006297917010102