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REVIEW: The Centrosome as the Main Integrator of Endothelial Cell Functional Activity

A. S. Shakhov and I. B. Alieva*

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia; E-mail: irina_alieva@belozersky.msu.ru

* To whom correspondence should be addressed.

Received January 18, 2017; Revision received January 31, 2017
The centrosome is an intracellular structure of the animal cell responsible for organization of cytoplasmic microtubules. According to modern concepts, the centrosome is a very important integral element of the living cell whose functions are not limited to its ability to polymerize microtubules. The centrosome localization in the geometric center of the interphase cell, the high concentration of various regulatory proteins in this area, the centrosome-organized radial system of microtubules for intracellular transport by motor proteins, the centrosome involvement in the perception of external signals and their transmission – all these features make this cellular structure a unique regulation and distribution center managing dynamic morphology of the animal cell. In conjunction with the tissue-specific features of the centrosome structure, this suggests the direct involvement of the centrosome in execution of cell functions. This review discusses the involvement of the centrosome in the vital activity of endothelial cells, as well as its possible participation in the implementation of barrier function, the major function of endothelium.
KEY WORDS: endothelium, endothelial cell, centrosome, centriole, primary cilium

DOI: 10.1134/S0006297917060037