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REVIEW: Design, Synthesis, and Some Aspects of the Biological Activity of Mitochondria-Targeted Antioxidants

G. A. Korshunova*, A. V. Shishkina, and M. V. Skulachev

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia; E-mail: korsh@genebee.msu.ru

* To whom correspondence should be addressed.

Received November 24, 2016; Revision received April 15, 2017
This review summarizes for the first time data on the design and synthesis of biologically active compounds of a new generation – mitochondria-targeted antioxidants, which are natural (or synthetic) p-benzoquinones conjugated via a lipophilic linker with (triphenyl)phosphonium or ammonium cations with delocalized charge. It also describes the synthesis of mitochondria-targeted antioxidants – uncouplers of oxidative phosphorylation – based on fluorescent dyes.
KEY WORDS: mitochondria, antioxidants, uncouplers of oxidative phosphorylation, benzoquinones, phosphonium and ammonium cations

DOI: 10.1134/S0006297917070021