* To whom correspondence should be addressed.
Received November 24, 2016; Revision received April 15, 2017
This review summarizes for the first time data on the design and synthesis of biologically active compounds of a new generation – mitochondria-targeted antioxidants, which are natural (or synthetic) p-benzoquinones conjugated via a lipophilic linker with (triphenyl)phosphonium or ammonium cations with delocalized charge. It also describes the synthesis of mitochondria-targeted antioxidants – uncouplers of oxidative phosphorylation – based on fluorescent dyes.
KEY WORDS: mitochondria, antioxidants, uncouplers of oxidative phosphorylation, benzoquinones, phosphonium and ammonium cations