[Back to Issue 2 ToC] [Back to Journal Contents] [Back to Biochemistry (Moscow) Home page]

REVIEW: Activation of Yeast Mitochondrial Translation: Who Is in Charge?

K. S. Derbikova1, S. A. Levitsky1, I. V. Chicherin1, E. N. Vinogradova1, and P. A. Kamenski1,2*

1Lomonosov Moscow State University, Faculty of Biology, 119991 Moscow, Russia; E-mail: peter@protein.bio.msu.ru

2Immanuel Kant Baltic Federal University, Institute of Living Systems, 236038 Kaliningrad, Russia

* To whom correspondence should be addressed.

Received August 26, 2017; Revision received October 3, 2017
Mitochondrial genome has undergone significant reduction in a course of evolution; however, it still contains a set of protein-encoding genes and requires translational machinery for their expression. Mitochondrial translation is of the prokaryotic type with several remarkable differences. This review is dedicated to one of the most puzzling features of mitochondrial protein synthesis, namely, the system of translational activators, i.e., proteins that specifically regulate translation of individual mitochondrial mRNAs and couple protein biosynthesis with the assembly of mitochondrial respiratory chain complexes. The review does not claim to be a comprehensive analysis of all published data; it is rather focused on the idea of the “core component” of the translational activator system.
KEY WORDS: mitochondria, ribosomes, translation, mRNA, translational activators, complex assembly

DOI: 10.1134/S0006297918020013